KMID : 0604020170320030240
|
|
Korean Journal of Critical Care Medicine 2017 Volume.32 No. 3 p.240 ~ p.246
|
|
Biochemical Markers as Predictors of In-Hospital Mortality in Patients with Severe Trauma: A Retrospective Cohort Study
|
|
Jang Ha-Nee
Park Hyun-Oh Yang Tae-Won Yang Jun-Ho Kim Sung-Hwan Moon Seong-Ho Byun Joung-Hun Lee Chung-Eun Kim Jong-Woo Kang Dong-Hun Baek Kyeong-Hee
|
|
Abstract
|
|
|
Background: Initial evaluation of injury severity in trauma patients is an important and challenging task. We aimed to assess whether easily measurable biochemical parameters (hemoglobin, pH, and prothrombin time/international normalized ratio [PT/INR]) can predict in-hospital mortality in patients with severe trauma.
Methods: This retrospective study involved review of the medical records of 315 patients with severe trauma and an injury severity score >15 who were managed at Gyeongsang National University Hospital between January 2005 and December 2015. We extracted the following data: in-hospital mortality, injury severity score, and initial hemoglobin level, pH, and PT/INR. The predictive values of these variables were compared using receiver operation characteristic curves.
Results: Of the 315 patients, 72 (22.9%) died. The in-hospital mortality rates of patients with hemoglobin levels <8.4 g/dl and ¡Ã8.4 g/dl were 49.8% and 9.9%, respectively (P < 0.001). At a cutoff hemoglobin level of 8.4 g/dl, the sensitivity and specificity values for mortality were 81.9% and 86.4%, respectively. At a pH cutoff of 7.25, the sensitivity and specificity values for mortality were 66.7% and 77.8%, respectively; 66.7% of patients with a pH <7.25 died versus 22.2% with a pH ¡Ã7.25 (P < 0.001). The in-hospital mortality rates for patients with PT/INR values ¡Ã1.4 and <1.4 were 37.5% and 16%, respectively (P < 0.001; sensitivity, 37.5%; specificity, 84%).
Conclusions: Using the suggested cutoff values, hemoglobin level, pH, and PT/INR can simply and easily be used to predict in-hospital mortality in patients with severe trauma.
|
|
KEYWORD
|
|
osis, hemoglobin, injuries, international normalized ratio, mortality
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|